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Mail Launch Failure

If Mail won't launch, and a message like "Mail cannot save information about your mailboxes because there isn’t enough space in your home folder" is displayed.

Check home directory access/permissions issue, then try deleting the file:
Envelope Index-journal
In folder: ~/Library/Mail
Or: ~/Library/Mail/V6/MailData
Or: substitute the correct V number for newer versions

Or from the terminal: cd ~/Library/Mail
Or: cd ~/Library/Mail/V6/MailData
Or: substitute the correct V number for newer versions (as above)
Then: rm Envelope\ Index-journal

That will force the sqlite database to reindex and a corrupt index can cause this error.